Resource Type

Journal Article 9

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2020 2

2019 2

2017 2

2016 1

2013 1

2009 1

Keywords

diabetic nephropathy 3

DQB1 1

IGA 1

IgA nephropathy 1

Kirchhoff-Love model 1

Shenkang injection 1

anti-ERK2 1

antiproliferative activity 1

apoptosis 1

association study 1

breast cancer 1

building information modelling 1

chronic allograft nephropathy 1

clinical characteristics 1

cohesive zone model 1

curriculum development 1

delamination 1

diagnosis 1

engineering communication 1

engineering education 1

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 507-516 doi: 10.1007/s11684-016-0475-6

Abstract:

Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis

Keywords： DQB1     human leukocyte antigen (HLA)     IgA nephropathy     haplotype     association study    

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Toward deep impacts of BIM on education

Žiga TURK, Andreja ISTENIČ STARČIČ

Frontiers of Engineering Management 2020, Volume 7, Issue 1,   Pages 81-88 doi: 10.1007/s42524-019-0035-2

Abstract: Building information models (BIM) provide a way to represent buildings and communicate about them. In teaching engineering, we also need representations of buildings and are communicating knowledge about them. While teaching engineering we refer to the very same real-world objects that have an explicit conceptualization in BIM. This explicit conceptualization did not exist in the age when design communication relied on drawings and documents. The question that this paper asks is this: due to BIM, communication in the industry has changed. Should communication of engineering knowledge – teaching – change as well and how? While much has been written about teaching BIM and incorporating BIM into the curricula, this paper is exploring the general impact of BIM on engineering education. It grounds earlier work (Turk, 2018) on insights from pedagogy. Five scenarios of the interplay between BIM-influenced engineering communication and teaching are presented. The paper argues that ignoring BIM may create a cognitive dissonance between academic learning and industrial work. We are finding that the impact of BIM is twofold: vertically there is a need to establish a reference between knowledge concepts (in teaching building) and information objects (in building information models). Horizontally BIM is an integration technology that allows for a more holistic design and planning. Both the language of individual courses as well as cross references and synergies among courses should change. A “T” style structure of the courses around BIM is proposed as a basis for integrated curriculum. Pedagogical approaches based on deep learning, model based learning and project based learning are suggested.

Keywords： engineering education     building information modelling     engineering communication     curriculum development    

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Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 618-625 doi: 10.1007/s11684-018-0620-5

Abstract: This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy

Keywords： multiparameter analysis     diagnosis     model     membranous nephropathy    

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Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 204-210 doi: 10.1007/s11684-009-0039-0

Abstract: underlying mechanism of adenovirus-mediated antisense ERK2 (Adanti-ERK2) gene therapy upon chronic allograft nephropathy

Keywords： anti-ERK2     renal transplantation     epithelial mesenchymal transition     chronic allograft nephropathy    

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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract: Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood.

Keywords： diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract:

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Isogeometric cohesive zone model for thin shell delamination analysis based on Kirchhoff-Love shell model

Tran Quoc THAI, Timon RABCZUK, Xiaoying ZHUANG

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 2,   Pages 267-279 doi: 10.1007/s11709-019-0567-x

Abstract: The isogeometric (IGA) thin shell model is based on Kirchhoff-Love theory.

Keywords： cohesive zone model     IGA     Kirchhoff-Love model     thin shell analysis     delamination    

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps: lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0, 2% enzyme/substrate (E/S) ratio, 15 h, and a solid to liquid ratio of 1 ∶ 10. The pectic extract showed a degree of polymerization (DP) profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5–25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen (4-OHT), a classical anticancer drug, which killed 56.5% of the cells.

Keywords： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: novel strategy for protecting against HG-induced renal tubular cell senescence in treatment of diabetic nephropathy

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Title Author Date Type Operation

DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Journal Article

Toward deep impacts of BIM on education

Žiga TURK, Andreja ISTENIČ STARČIČ

Journal Article

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

Journal Article

Adenovirus-mediated antisense ERK2 gene therapy ameliorates chronic allograft nephropathy in a rat model

Zhao DING, Zhishui CHEN, Xilin CHEN, Ming CAI, Hui GUO, Nianqiao GONG

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Isogeometric cohesive zone model for thin shell delamination analysis based on Kirchhoff-Love shell model

Tran Quoc THAI, Timon RABCZUK, Xiaoying ZHUANG

Journal Article

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

IGA

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article